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  • Methylene Blue Vasopressor: Mechanisms and Hemodynamics
    Methylene blue exerts its vasopressor effects by inhibiting the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway, a key regulator of vascular tone Under normal conditions, endothelial cells produce NO, which activates soluble guanylate cyclase (sGC) in vascular smooth muscle cells
  • Effect of a single bolus of methylene blue prophylaxis on . . .
    Methylene blue (MB) is an inhibitory drug of inducible NO We aimed to evaluate the effect of prophylactic MB administration before CPB on vasopressor and transfusion requirements in patients with IE undergoing valvular heart surgery (VHS)
  • What to know about methylene blue - Harvard Health
    Diseases Conditions What to know about methylene blue Once used to dye cotton and treat malaria, methylene blue is gaining attention for a variety of off-label uses Learn where it started, how it works, and what the evidence says about its safety and health benefits
  • Methylene blue: a controversial diagnostic acid and medication?
    MB reduces cyclic guanosine monophosphate (cGMP) concentration via guanylate cyclase inhibition (which causes relaxation of smooth muscle tissue of the vasculature) and thus has a vasoconstrictive effect 39 Along with its ability to counteract the effect of NO, the complex image of MB action 22,40–42 is completed by mentioning its
  • Vasopressor-Sparing Action of Methylene Blue in Severe Sepsis . . .
    Methylene blue (MB) represents an additional option useful to provide a catecholamine-sparing effect, but its use is controversial This review aims to summarize current evidence for MB as adjuvant therapy in critically ill patients with distributive shock
  • Cardiac Arrest and Neuroprotection by Methylene Blue
    As a result, there is an increase in vascular permeability, blood clotting activation, platelet activation, and vasoconstrictors release, contributing to the regional flow reduction Cerebral edema increased blood-brain barrier (BBB) permeability and neurological damage are seen early in ischemia-induced by cardiac arrest
  • Methylene Blue | SpringerLink
    Methylene Blue and Coagulation MB can be reduced in platelet aggregation for its consequences in the NO cGMP pathway Reduced platelet aggregation has been confirmed using experimental models of animals with damaged epithelium in the presence of MB [1]





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