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    This systematic review explores the real-world effectiveness and safety of biologic therapies for moderate-to-severe ulcerative colitis Vedolizumab and tofacitinib were the most assessed therapies, with higher remission rates observed for tofacitinib compared with vedolizumab and for vedolizumab compared with anti-TNFα
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    Advanced therapies for ulcerative colitis (UC) continue to emerge, creating a complex and growing landscape of treatment options Afimkibart, a TL1Abinding antibody, demonstrated promising efficacy in TUSCANY-2, a phase 2b trial 1 We utilize indirect comparison methods to compare the efficacy of afimkibart versus adalimumab, an anti-TNF therapy, as firstline therapeutics
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    Treatment of Ulcerative Colitis For mild-to-moderate ulcerative colitis, start with high-dose oral 5-ASA (mesalamine 2 4-4 8 g day) combined with rectal 5-ASA therapy, and escalate to oral prednisolone 40 mg daily if no response within 2-4 weeks; for moderate-to-severe disease, use advanced therapies (infliximab, vedolizumab, upadacitinib, or ustekinumab) as first-line treatment, with
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    The aim of this retrospective observational study is to investigate and compare the real-world effectiveness and safety of upadacitinib when used as first-line exposure versus rescue exposure in patients with acute severe ulcerative colitis (ASUC)
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    A RECENT retrospective cohort study comparing the effectiveness of upadacitinib and tofacitinib in patients with ulcerative colitis (UC) has shown that upadacitinib may lead to better disease-specific outcomes at 12 months The authors used the TriNetX multi-institutional database to compare the





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