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BRL-44408 - Wikipedia
BRL-44408 is a drug used in scientific research which acts as a selective antagonist for the α 2A -adrenergic receptor [1] It has been suggested as having potential therapeutic application in the treatment of extrapyramidal side effects produced by some antipsychotic medications
BRL-44408 maleate | α2A-adrenoceptor antagonist | MedChemExpress
BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8 5 nM) BRL-44408 maleate has antidepressant and analgesic activity BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury
BRL 44408 maleate, alpha2A adrenoceptor antagonist - Abcam
Selective α 2A adrenoceptor antagonist (K i values are 5 68 and 651 nM for α 2A and α 2B, respectively) Centrally active following subcutaneous administration Demonstrates antidepressant and analgesic activity 681806-46-2 >99% Solid 331 37 g mol Synthetic Soluble in water to 100 mM
BRL-44408 maleate | C17H21N3O4 | CID 10382026 - PubChem
BRL-44408 maleate | C17H21N3O4 | CID 10382026 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety hazards toxicity information, supplier lists, and more
BRL 44408 maleate | Adrenergic α2 Receptors | Tocris Bioscience
BRL 44408 maleate is a selective α2A -adrenoceptor antagonist (K = 1 7 nM and 144 5 nM at α2A and α2B -adrenergic receptors respectively) Increases hippocampal noradrenalin release following systemic administration
BRL 44408 maleate salt ≥98% (HPLC) | Sigma-Aldrich
BRL 44408 maleate is a selective α 2A -adrenoceptor antagonist This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction To browse other handbook pages, click here This compound was developed by GlaxoSmithKline
BRL 44408 (maleate) (CAS 681806-46-2) - Cayman Chemical
BRL 44408 inhibits forskolin-stimulated cAMP accumulation with an IC 50 value of 92 3 nM in CHO cells expressing the recombinant human α 2A -AR It increases norepinephrine and dopamine levels by 200 and 100%, respectively, in rat medial prefrontal cortex when administered at a dose of 10 mg kg
BRL-44408 maleate | MedChemExpress
BRL-44408 maleate is a selective, blood-brain barrier-permeable α2A-adrenergic receptor antagonist with a Ki value of 8 56 nM against human targets
BRL-44408 - Drug Targets, Indications, Patents - Synapse
Dexmedetomidine alleviated LPS-CM-induced impairment of neurogenesis in a dose-dependent manner Yohimbine, as well as BRL-44408, reversed the effects of dexmedetomidine We established a mouse model of SAE via cecal ligation and perforation (CLP)

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